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Progesterone naturally begins to decline around age 30, and by age 50 has decreased significantly. According to the late Dr. John Lee (leading progesterone specialist), estrogen levels drop only 40-60% at menopause, just enough for the monthly cycles to stop. Sadly, progesterone levels may drop to near zero in some women causing hot flashes, night sweats, insomnia and other troubling symptoms. Stress, endocrine-disrupting chemicals, and xenoestrogens all accelerate the progesterone decline. During perimenopause and menopause, the sharp decline of progesterone can lead to estrogen dominance – despite lower estrogen levels.